When I first moved to Hotwells, there were still signs for the famous transport caff "Popeye's Diner", a well-known refuelling point for truckers on the way in or out of Bristol. It was also the cafe used for interior shots in some episodes of Only Fools and Horses. You can see it as it used to be in the "Trigger's broom" sketch, for one. These days it's a much posher affair, and they do a very good Eggs Benedict when they're open.
You can see a before/after comparison of how the interior looked when I moved to the area in the 1990s and how it looks now in this shot on Flickr that compares an Only Fools and Horses still with a modern shot.
GPS Coordinates:
51.44756, -2.62086
Location: Spike Island